I think it's definitely about how messed up and overused advertising is, and I think Serj and Daron decided to use pizza advertising as one example. Notice how braggy and... well, annoying it sounds, "What a splendid pie!".
Companies are ALWAYS praising how amazing their products are in commercials and such. And I think "every minute, every second, buy buy buy buy buy!" kind of speaks for itself, doesn't it? The companies are just telling the people watching the commercial to keep buy their product(s) over and over again.
Now, as for "need therapy, therapy, advertising causes need," I think Serj and Daron are saying that whenever people see something they like in a commercial, they automatically need it. And sometimes it can get to the point where you're overwhelmed with all the stuff you think you need, as if you need therapy or something.
"Advertising's got you on the run..." Well I think this line just proves that this song is clearly about advertising. System tends to use a combination of completely obvious and seemingly nonsensical lines in their songs in order to get their points across. And I think this line literally means that with all this advertising it may feel like we constantly need to be out of the house, shopping for groceries, clothes, etc.
Now as for the intro, I can't give an exact interpretation.
"Ball game's in the refrigerator, door's closed, lights are out, butter's getting hard."
I don't know how to interpret the ball game part, but the rest of it seems to be saying that when the refrigerator door closes the light automatically turns off, and the butter in the refrigerator starts to get hard because of all the cold trapped inside. And now as I take a step back and look at it all, I say to myself, "Congratulations. You just very poorly interpreted something and made it something that needs to be interpreted."
Really, I have no idea what the intro is about other than the fact people typically store frozen pizzas in the refrigerator. But oh well. I think one of the best parts about System is that half the time we don't know what they're talking about. So maybe we're better off...
Hope I helped.
